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PepPredictor

Online server: https://peppredictor.pages.dev/

PepPredictor is a web platform for sequence-derived peptide property profiling, developability scoring, and early-stage risk flagging. It accepts pasted peptide sequences, FASTA text, or uploaded FASTA/TXT files, then reports peptide developability-related descriptors with downloadable results.

Public Access

The Cloudflare Pages site is the recommended public entry point.

Inputs

  • FASTA records
  • One or more peptide sequences separated by comma, semicolon, pipe, space, tab, or new line
  • Canonical amino acids only: ACDEFGHIKLMNPQRSTVWY
  • Up to 5000 sequences per run

Outputs

  • Net charge at pH 7.4
  • Net charge at pH 7.0
  • Molecular weight
  • Isoelectric point
  • Hydrophobicity
  • Amphiphilicity
  • Instability index
  • Aliphatic index
  • GRAVY
  • Boman index
  • Shannon entropy
  • Aromaticity
  • Residue class fractions
  • Extinction coefficient at 280 nm
  • Solubility proxy
  • Aggregation risk proxy
  • Degradation hotspot scan
  • Proteolysis risk proxy
  • N-end rule class
  • SPPS difficulty score
  • Hemolysis risk proxy
  • Weighted developability score
  • Hard-filter report
  • PASS/FAIL classification
  • CSV download for all results or PASS-only results

Note

PepPredictor is intended for early-stage computational screening. Its results do not represent experimental validation or clinical druggability conclusions.

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Sequence-derived peptide property profiling and early-stage developability scoring.

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