Resistance landscape of the MET kinase domain

Source code for the MET kinase domain inhibitor DMS

please cite:

Estevam, G. O., Linossi, E. M., Rao, J., Macdonald, C. B., Ravikumar, A., Chrispens, K. M., Capra, J. A., Coyote-Maestas, W., Pimentel, H., Collisson, E. A., Jura, N., & Fraser, J. S. (2024). Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning (p. 2024.07.16.603579). bioRxiv. https://doi.org/10.1101/2024.07.16.603579

Analysis code used in the manuscript found in the "Data" folder

Machine learning code and analysis can be found in the "Machine Learning" folder