CalculateOraScore: "Failed to connect to the API Server" during ORA

[TimothyVoss99]

Dear MetaboAnalystR team,

I am currently building a pipeline using MetaboAnalystR and have encountered a connection issue when performing Pathway Analysis.

Description:
When following the Pathway Analysis Vignette (https://www.metaboanalyst.ca/resources/vignettes/Pathway_Analysis.html) and executing the CalculateOraScore function (mSet <- CalculateOraScore(mSet, "rbc", "hyperg")), the connection to the API server fails.

Actual Behavior / Error Log:

[1] "Loaded files from MetaboAnalyst web-server."
[1] "Failed to connect to the API Server!"
[1] "Failed to perform pathway analysis!

Questions:

Is the API endpoint currently down or has the address changed?

Is there a workaround to perform this calculation locally without the API dependency?

System Information:

MetaboAnalystR version: [4.2.0]

Thank you for your help.

Best, Timothy

@Zhiqiang-PANG

[codeonome]

Hello @TimothyVoss99
I am facing the same issue, were you able to resolve it?

Thanks,
Apoorva