diff --git a/docs/changelog.rst b/docs/changelog.rst
index 0e653e0..5f0896d 100644
--- a/docs/changelog.rst
+++ b/docs/changelog.rst
@@ -15,6 +15,7 @@ Changelog
    applied. Uninstalling from the same panel removes the PAS plugin
    and the per-user JWT signing secrets.
 
+- #102 Support DX Duration (Timedelta) fields via a field manager
 - #101 Encode AT string field values to native str before validation
 - #100 Normalize UID references through the field manager, not the setter
 - #99 Report the reason when object creation fails
diff --git a/src/senaite/jsonapi/configure.zcml b/src/senaite/jsonapi/configure.zcml
index 884a5bf..cd6046e 100644
--- a/src/senaite/jsonapi/configure.zcml
+++ b/src/senaite/jsonapi/configure.zcml
@@ -258,6 +258,12 @@
       factory=".fieldmanagers.DatetimeFieldManager"
       />
 
+  <!-- Adapter for DX Duration (Timedelta) Fields -->
+  <adapter
+      for="senaite.core.schema.interfaces.IDurationField"
+      factory=".fieldmanagers.DurationFieldManager"
+      />
+
   <!-- Adapter for Named Image Fields -->
   <adapter
       for="plone.namedfile.interfaces.INamedImageField"
diff --git a/src/senaite/jsonapi/datamanagers.py b/src/senaite/jsonapi/datamanagers.py
index f1a20e6..ad3d3e2 100644
--- a/src/senaite/jsonapi/datamanagers.py
+++ b/src/senaite/jsonapi/datamanagers.py
@@ -31,8 +31,15 @@
 from senaite.jsonapi import api
 from senaite.jsonapi.interfaces import IDataManager
 from senaite.jsonapi.interfaces import IFieldManager
+from senaite.jsonapi.fieldmanagers import DurationFieldManager
 from senaite.jsonapi.fieldmanagers import UIDReferenceFieldMixin
 
+# Field managers that normalize the incoming value (resolve UIDs, coerce
+# a duration mapping to a timedelta, ...). For these the raw set<Name>
+# mutator would store the value unconverted, so the data manager must go
+# through the field manager instead of the setter.
+NORMALIZING_FIELD_MANAGERS = (UIDReferenceFieldMixin, DurationFieldManager)
+
 
 class BaseDataManager(object):
     """Base Data Manager
@@ -231,14 +238,15 @@ def set(self, name, value, **kw):
 
         field = api.get_field(self.context, name)
 
-        # UID reference fields must be set via their field manager, which
-        # normalizes the value (resolves objects/paths and coerces UIDs
-        # to native str). A raw setter would store the value as given --
-        # e.g. a unicode UID from a JSON payload -- which then fails the
-        # field's ASCIILine value_type validation with WrongContainedType.
+        # Fields whose manager normalizes the value must be set via that
+        # manager (e.g. UID references coerced to native str, or a
+        # duration mapping coerced to a timedelta). A raw setter would
+        # store the value as given -- a unicode UID that fails the
+        # ASCIILine value_type, or a dict that a Timedelta field rejects
+        # as "wrong type".
         if field is not None:
             fieldmanager = IFieldManager(field)
-            if isinstance(fieldmanager, UIDReferenceFieldMixin):
+            if isinstance(fieldmanager, NORMALIZING_FIELD_MANAGERS):
                 return fieldmanager.set(self.context, value, **kw)
 
         # Otherwise prefer a content-type setter: it may carry side
diff --git a/src/senaite/jsonapi/fieldmanagers.py b/src/senaite/jsonapi/fieldmanagers.py
index 298b9f7..4b24d05 100644
--- a/src/senaite/jsonapi/fieldmanagers.py
+++ b/src/senaite/jsonapi/fieldmanagers.py
@@ -24,6 +24,7 @@
 import six
 from AccessControl import Unauthorized
 from bika.lims import api as bika_api
+from datetime import timedelta
 from DateTime import DateTime
 from Products.Archetypes.utils import mapply
 from senaite.core.schema.uidreferencefield import UIDReferenceField
@@ -149,6 +150,58 @@ def json_data(self, instance, default=None):
         return api.to_iso_date(value, default=default)
 
 
+class DurationFieldManager(ZopeSchemaFieldManager):
+    """Adapter to get/set DX DurationField (zope.schema Timedelta) values.
+
+    The stored value is a `datetime.timedelta`, which JSON cannot carry.
+    Accept a `{"days", "hours", "minutes", "seconds"}` mapping (or a
+    number of minutes, or a timedelta) on set, and serialize back to that
+    mapping.
+    """
+    interface.implements(IFieldManager)
+
+    UNITS = ("weeks", "days", "hours", "minutes", "seconds")
+
+    def set(self, instance, value, **kw):
+        value = self.to_timedelta(value)
+        self.field.validate(value)
+        return self.field.set(instance, value)
+
+    def json_data(self, instance, default=None):
+        value = self.get(instance)
+        if not isinstance(value, timedelta):
+            return default
+        return self.to_mapping(value)
+
+    @classmethod
+    def to_timedelta(cls, value):
+        if value is None or isinstance(value, timedelta):
+            return value
+        if isinstance(value, dict):
+            kwargs = {}
+            for unit in cls.UNITS:
+                num = value.get(unit)
+                if num:
+                    kwargs[unit] = float(num)
+            return timedelta(**kwargs)
+        if isinstance(value, (int, float)):
+            return timedelta(minutes=value)
+        return value
+
+    @staticmethod
+    def to_mapping(value):
+        total = int(value.total_seconds())
+        days, rem = divmod(total, 86400)
+        hours, rem = divmod(rem, 3600)
+        minutes, seconds = divmod(rem, 60)
+        return {
+            "days": days,
+            "hours": hours,
+            "minutes": minutes,
+            "seconds": seconds,
+        }
+
+
 class RichTextFieldManager(ZopeSchemaFieldManager):
     """Adapter to get/set the value of Rich Text Fields
     """
diff --git a/src/senaite/jsonapi/tests/doctests/create.rst b/src/senaite/jsonapi/tests/doctests/create.rst
index 1d4bde3..0f2fa2e 100644
--- a/src/senaite/jsonapi/tests/doctests/create.rst
+++ b/src/senaite/jsonapi/tests/doctests/create.rst
@@ -339,6 +339,17 @@ them (they expect a native `str`):
     >>> nitrate.getPrice()
     '12.50'
 
+A DX Duration field (`zope.schema.Timedelta`) cannot be carried by JSON
+directly; it accepts a `{days, hours, minutes, seconds}` mapping:
+
+    >>> data = {"portal_type": "SamplePoint",
+    ...         "parent_path": api.get_path(portal.setup.samplepoints),
+    ...         "title": "Well 1",
+    ...         "sampling_frequency": {"days": 7}}
+    >>> sample_point = create_json(data)
+    >>> sample_point.sampling_frequency
+    datetime.timedelta(7)
+
 
 Creating a Sample
 ~~~~~~~~~~~~~~~~~