diff --git a/CHANGELOG.md b/CHANGELOG.md
index b4e3a6539e..0585a1c438 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -156,6 +156,7 @@
 - Update template components ([#3328](https://github.com/nf-core/tools/pull/3328))
 - Template: Remove mention of GRCh37 if igenomes is skipped ([#3330](https://github.com/nf-core/tools/pull/3330))
 - Be more verbose in approval check action ([#3338](https://github.com/nf-core/tools/pull/3338))
+- Add `gpu` profile ([#3272](https://github.com/nf-core/tools/pull/3272))
 
 ### Download
 
diff --git a/nf_core/pipeline-template/conf/base.config b/nf_core/pipeline-template/conf/base.config
index 16a4fe6cdf..9f51eb7cd5 100644
--- a/nf_core/pipeline-template/conf/base.config
+++ b/nf_core/pipeline-template/conf/base.config
@@ -59,4 +59,7 @@ process {
         errorStrategy = 'retry'
         maxRetries    = 2
     }
+    withLabel: process_gpu {
+        ext.use_gpu = { workflow.profile.contains('gpu') }
+    }
 }
diff --git a/nf_core/pipeline-template/nextflow.config b/nf_core/pipeline-template/nextflow.config
index 0bad472b2c..3e0e281073 100644
--- a/nf_core/pipeline-template/nextflow.config
+++ b/nf_core/pipeline-template/nextflow.config
@@ -197,6 +197,11 @@ profiles {
         }
     }
     {%- endif %}
+    gpu {
+        docker.runOptions       = '-u $(id -u):$(id -g) --gpus all'
+        apptainer.runOptions    = '--nv'
+        singularity.runOptions  = '--nv'
+    }
     {%- if test_config %}
     test      { includeConfig 'conf/test.config'      }
     test_full { includeConfig 'conf/test_full.config' }