diff --git a/packages/grpc-js/test/test-client.ts b/packages/grpc-js/test/test-client.ts
index bbb3f063f..0ac803edc 100644
--- a/packages/grpc-js/test/test-client.ts
+++ b/packages/grpc-js/test/test-client.ts
@@ -124,6 +124,12 @@ describe('Client with a nonexistent target domain', () => {
     client.close();
   });
   it('should fail multiple calls', function (done) {
+    if (process.platform === 'win32') {
+      // DNS has some weird behavior on Windows
+      this.skip();
+      // @ts-ignore: Unreachable code error
+      return;
+    }
     this.timeout(5000);
     // Regression test for https://github.com/grpc/grpc-node/issues/1411
     client.makeUnaryRequest(
diff --git a/packages/grpc-js/test/test-idle-timer.ts b/packages/grpc-js/test/test-idle-timer.ts
index ed6af2cf7..34381476b 100644
--- a/packages/grpc-js/test/test-idle-timer.ts
+++ b/packages/grpc-js/test/test-idle-timer.ts
@@ -132,7 +132,15 @@ describe('Channel idle timer', () => {
 describe('Channel idle timer with UDS', () => {
   let server: TestServer;
   let client: TestClient | null = null;
-  before(() => {
+  before(function() {
+    if (process.platform === 'win32') {
+      /* The Node API that creates a UDS on Linux actually creates a named
+       * pipe on Windows, and those have a different naming scheme than UDS
+       * so the test setup doesn't work on Windows. */
+      this.skip();
+      // @ts-ignore: Unreachable code error
+      return;
+    }
     server = new TestServer(false);
     return server.startUds();
   });
@@ -142,7 +150,15 @@ describe('Channel idle timer with UDS', () => {
       client = null;
     }
   });
-  after(() => {
+  after(function () {
+    if (process.platform === 'win32') {
+      /* The Node API that creates a UDS on Linux actually creates a named
+       * pipe on Windows, and those have a different naming scheme than UDS
+       * so the test setup doesn't work on Windows. */
+      this.skip();
+      // @ts-ignore: Unreachable code error
+      return;
+    }
     server.shutdown();
   });
   it('Should be able to make a request after going idle', function (done) {