IEDB SRC proteins not in ONTIE

[beckyjackson]

There are 400 SRC proteins in the IEDB source table that are not in ONTIE. Of these, 189 are inactive or related, so they don't appear anywhere in the protein tree. Of the remaining 211, 73 of them are assigned to parent proteins so their taxon-protein IRIs don't appear in the tree anyway. That leaves 138 SRC proteins that are not in ONTIE (see table below).

Questions:

• Do we want to add them? (Other SRCs that do have ONTIE IDs currently use their ONTIE IRI in the protein tree)
• Do we want to add the 73 that are only used as synonyms for parent proteins?
• Do we want to add related and/or inactive SRCs?

Name	Accession	Org ID	Org Name
Fibroblast Activation Protein 2	SRC528250	851	Fusobacterium nucleatum
14 kDa antigen	SRC546476	1773	Mycobacterium tuberculosis
cation-transporting P-type ATPase	SRC552198	1773	Mycobacterium tuberculosis
thioredoxin family protein	SRC551284	2261	Pyrococcus furiosus
DNA translocase	SRC536882	5476	Candida albicans
Tryptophan-Threonine-rich plasmodium antigen C terminal	SRC528077	5821	Plasmodium berghei
Saposin B domain-containing protein	SRC522283	6182	Schistosoma japonicum
micro exon gene 12	SRC536327	6182	Schistosoma japonicum
SJCHGC06871 protein	SRC536328	6182	Schistosoma japonicum
cathepsin D (lysosomal aspartyl protease)	SRC536329	6182	Schistosoma japonicum
hypothetical protein EWB00_009944	SRC536330	6182	Schistosoma japonicum
micro exon gene 11	SRC536331	6182	Schistosoma japonicum
micro exon gene 14	SRC536332	6182	Schistosoma japonicum
micro exon gene 15	SRC536333	6182	Schistosoma japonicum
micro exon gene 19	SRC536334	6182	Schistosoma japonicum
micro exon gene 22	SRC536335	6182	Schistosoma japonicum
micro exon gene 26.1	SRC536336	6182	Schistosoma japonicum
micro exon gene 26.2	SRC536337	6182	Schistosoma japonicum
micro exon gene 26.4	SRC536338	6182	Schistosoma japonicum
micro exon gene 26.5	SRC536339	6182	Schistosoma japonicum
micro exon gene 26.6	SRC536340	6182	Schistosoma japonicum
micro exon gene 29	SRC536341	6182	Schistosoma japonicum
micro exon gene 4.1 C	SRC536342	6182	Schistosoma japonicum
micro exon gene 4.1 N	SRC536343	6182	Schistosoma japonicum
micro exon gene 4.2	SRC536344	6182	Schistosoma japonicum
micro exon gene 8.1 C	SRC536345	6182	Schistosoma japonicum
micro exon gene 8.2 C	SRC536346	6182	Schistosoma japonicum
micro exon gene 8.3 C	SRC536347	6182	Schistosoma japonicum
micro exon gene 8.4	SRC536348	6182	Schistosoma japonicum
micro exon gene 9	SRC536349	6182	Schistosoma japonicum
micro exon gene n.1	SRC536350	6182	Schistosoma japonicum
micro exon gene n.2	SRC536351	6182	Schistosoma japonicum
Group XV phospholipase A2	SRC536352	6182	Schistosoma japonicum
palmitoyl-protein thioesterase 1	SRC536353	6182	Schistosoma japonicum
tetraspanin-CD63 receptor isoform 1	SRC536354	6182	Schistosoma japonicum
25 kDa integral membrane protein isoform 2	SRC536355	6182	Schistosoma japonicum
SJCHGC01839 protein	SRC536356	6182	Schistosoma japonicum
phospholipase A1	SRC536883	6182	Schistosoma japonicum
integrin beta-1	SRC536939	9031	Gallus gallus (chicken)
Ptal-N*01:01	SRC516267	9402	Pteropus alecto (black flying fox)
APOBEC-3C	SRC552219	9541	Macaca fascicularis (crab eating macaque)
HLA class I A2	SRC505873	9606	Homo sapiens (human)
ribonuclease P 25kDa subunit	SRC517406	9606	Homo sapiens (human)
Histone H3	SRC522013	9606	Homo sapiens (human)
collagen alpha-1(IV) chain	SRC522285	9606	Homo sapiens (human)
serine/threonine kinase 35	SRC526348	9606	Homo sapiens (human)
tau-tubulin kinase 1	SRC526349	9606	Homo sapiens (human)
Septin-1	SRC526350	9606	Homo sapiens (human)
mannose-1-phosphate guanyltransferase alpha	SRC526351	9606	Homo sapiens (human)
basigin (Ok blood group)	SRC526352	9606	Homo sapiens (human)
Complement component 4 binding protein, alpha	SRC526353	9606	Homo sapiens (human)
8.2 kDa differentiation factor	SRC526354	9606	Homo sapiens (human)
Neuregulin 3	SRC526355	9606	Homo sapiens (human)
TRAF3 interacting protein 3	SRC526356	9606	Homo sapiens (human)
Band 4.1-like protein 2	SRC526357	9606	Homo sapiens (human)
ATP synthase subunit beta, mitochondrial	SRC526358	9606	Homo sapiens (human)
Galectin-1	SRC526359	9606	Homo sapiens (human)
fibronectin type III domain-containing protein 1	SRC528028	9606	Homo sapiens (human)
wingless-type MMTV integration site family, member 11	SRC528029	9606	Homo sapiens (human)
apolipoprotein A-I	SRC529349	9606	Homo sapiens (human)
PDZ domain-containing protein MAGIX	SRC530329	9606	Homo sapiens (human)
high-mobility group nucleosome binding domain 1	SRC530330	9606	Homo sapiens (human)
Melanocyte Protein Pmel 17	SRC536071	9606	Homo sapiens (human)
CEA cell adhesion molecule 18	SRC541537	9606	Homo sapiens (human)
5'-nucleotidase, cytosolic IIIB	SRC541538	9606	Homo sapiens (human)
FAM161 centrosomal protein A	SRC541539	9606	Homo sapiens (human)
serine protease 3	SRC541540	9606	Homo sapiens (human)
leukocyte immunoglobulin like receptor B3	SRC541541	9606	Homo sapiens (human)
pentraxin 4	SRC541542	9606	Homo sapiens (human)
N-acetyllactosaminide alpha-1,3-galactosyltransferase	SRC541543	9606	Homo sapiens (human)
leukocyte immunoglobulin like receptor A6	SRC541544	9606	Homo sapiens (human)
ATP-dependent RNA helicase DHX33	SRC541699	9606	Homo sapiens (human)
protein YIPF1	SRC541700	9606	Homo sapiens (human)
serine/threonine-protein kinase 32C	SRC541701	9606	Homo sapiens (human)
Proline and serine-rich protein 1	SRC542907	9606	Homo sapiens (human)
calcitonin	SRC542908	9606	Homo sapiens (human)
usherin	SRC543193	9606	Homo sapiens (human)
Golgin subfamily A member 6-like protein 2	SRC543194	9606	Homo sapiens (human)
glutamate receptor 3	SRC546506	9606	Homo sapiens (human)
Calreticulin	SRC547807	9606	Homo sapiens (human)
Zinc finger protein 568	SRC549076	9606	Homo sapiens (human)
Sorting nexin 11	SRC549078	9606	Homo sapiens (human)
heterogeneous nuclear ribonucleoprotein M4	SRC549097	9606	Homo sapiens (human)
multidrug resistance-associated protein 9	SRC549098	9606	Homo sapiens (human)
NACHT, LRR and PYD domains-containing protein	SRC549099	9606	Homo sapiens (human)
hairy-related transcription factor 3	SRC549100	9606	Homo sapiens (human)
GnTV intron	SRC549105	9606	Homo sapiens (human)
Cytoskeleton-associated protein 2	SRC549757	9606	Homo sapiens (human)
solute carrier family 35 member G2	SRC549760	9606	Homo sapiens (human)
zinc finger FYVE-type containing 19	SRC549763	9606	Homo sapiens (human)
Double PHD fingers 1	SRC549764	9606	Homo sapiens (human)
TGFB induced factor homeobox 1	SRC549765	9606	Homo sapiens (human)
G protein subunit alpha i2	SRC549766	9606	Homo sapiens (human)
transforming growth factor, beta receptor II	SRC550094	9606	Homo sapiens (human)
TATA box-binding protein-associated factor RNA polymerase I subunit B	SRC550095	9606	Homo sapiens (human)
alternative protein ASTE1	SRC550096	9606	Homo sapiens (human)
double homeobox protein 4-like	SRC551377	9606	Homo sapiens (human)
Myristoylated alanine-rich C-kinase substrate	SRC551530	9606	Homo sapiens (human)
Parathyroid hormone-related protein	SRC551531	9606	Homo sapiens (human)
Putative uncharacterized protein GAFA-1	SRC551532	9606	Homo sapiens (human)
Solute carrier family 22 member 9	SRC551533	9606	Homo sapiens (human)
ADAMTS-like protein 1	SRC551534	9606	Homo sapiens (human)
Activin receptor type-2A	SRC551535	9606	Homo sapiens (human)
Protein BANP	SRC551536	9606	Homo sapiens (human)
Protein asteroid homolog 1	SRC551537	9606	Homo sapiens (human)
SMAD5 antisense gene protein 1	SRC551538	9606	Homo sapiens (human)
Putative uncharacterized protein encoded by LINC00615	SRC551539	9606	Homo sapiens (human)
C1q receptor protein	SRC551541	9606	Homo sapiens (human)
Insulin and Receptor-type tyrosine-protein phosphatase-like N	SRC551884	9606	Homo sapiens (human)
Receptor-type tyrosine-protein phosphatase-like N	SRC551885	9606	Homo sapiens (human)
Neuroendocrine protein 7B2	SRC551886	9606	Homo sapiens (human)
Hepatocyte Nuclear Factor 6	SRC551887	9606	Homo sapiens (human)
RNA exonuclease 2	SRC551888	9606	Homo sapiens (human)
Bone Morphogenetic Protein Receptor Type 1B	SRC557624	9606	Homo sapiens (human)
mlrq-like protein	SRC505861	10090	Mus musculus (mouse)
spectrin	SRC507716	10090	Mus musculus (mouse)
N-myc	SRC507717	10090	Mus musculus (mouse)
myelin P2 protein	SRC543542	10116	Rattus norvegicus (brown rat)
VACAC2_210	SRC549096	10245	Vaccinia virus (vaccinia virus VV)
polymerase	SRC506611	10407	Hepatitis B virus (hepatitis B virus (HBV))
envelope glycoprotein	SRC499792	11642	Simian foamy virus
gag protein	SRC528257	11723	Simian immunodeficiency virus (Chimpanzee immunodeficiency virus)
ORF1ab polyprotein	SRC522284	28344	Porcine reproductive and respiratory syndrome virus
envelope glycoprotein Q	SRC549211	32604	Human betaherpesvirus 6B (Human herpes virus 6B)
unknown protein eluted from bat MHC allele	SRC499793	32644	Unidentified
sigma A protein	SRC516038	38170	Avian orthoreovirus (Avian reovirus)
apoptosis protein	SRC550050	46221	Porcine circovirus
Three-finger toxin 3FTx	SRC520746	54390	Micrurus corallinus (painted coral snake)
2-oxoacid:acceptor oxidoreductase	SRC549212	63363	Aquifex aeolicus
PrgI family protein	SRC543255	97253	Eubacterium plexicaudatum
response regulator transcription factor	SRC543256	97253	Eubacterium plexicaudatum
Exo m 1	SRC522165	345840	Palaemon modestus
Large T antigen	SRC517438	1891726	Human polyomavirus 5

[jamesaoverton]

@rvita?

[rvita]

we add new src every week and all of them need to be added to ontie. but as part of the protein tree recuration task, we have also been editing the term names and synonyms of many of the existing src, so ontie will need to be updated to have the correct labels and synonyms for any pre-existing src that are lareday in ontie and to also add all new src, but this ontie activity should wait until we are done b/c we have a large set of src that are not in use and we will be deleting those after we confirm why they are not in use. i will update this ticket when we are done.